Sitagliptin-d 6

Overview

Sitagliptin -d 6 (MK-0431-d 6 ) is deuterium labeled Sitagliptin ( HY-13749 ). Sitagliptin is an orally active and highly selective DPP4 inhibitor with an IC 50 value of 19 nM. Sitagliptin blocks the degradation of glucagon-like peptide-1 ( GLP-1 ) and glucose-dependent insulinotropic peptide ( GIP ) by competing inhibition mechanism ( Kᵢ = 1 nM), thereby increasing the level of active incretin. Sitagliptin can also directly stimulate the secretion of GLP-1 by intestinal L cells by activating the cAMP/PKA and ERK1/2 pathways, and this effect is independent of DPP-4 . Sitagliptin shows protective effects on pancreatic islet grafts in 1-type diabetes models. Sitagliptin can be used for the study of 1-type and 2-type diabetes.

Application

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Product Information

• Catalog No.: HY-13749S3
• CAS No.: 1133211-99-0
• Molecular Formula: C16H9D6F6N5O
• Molecular Weight: 413.35
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source