ML267 is a blood-brain barrier permeable Antibacterial agent and bacterial phosphopantetheinyl transferase ( PPTase ) inhibitor, with an IC 50 of 0.29 μM against Bacillus subtilis Sfp-PPTase and an IC 50 of 8.1 μM against bacterial AcpS-PPTase. ML267 attenuates bacterial secondary metabolism, activity, and the production of Sfp-PPTase -dependent metabolites. ML267 inhibits the growth of Gram-positive bacteria, including Methicillin ( HY-121544 )-resistant Staphylococcus aureus . ML267 is applicable to research related to bacterial infections, including methicillin-resistant Staphylococcus aureus infections.
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