NS8593

Overview

NS8593 is an SK channel (small conductance Ca 2+ -activated K+ channels) inhibitor. NS8593 reversibly inhibited recombinant SK3-mediated currents (human SK3 and rat SK3). NS8593 inhibits all the SK1-3 subtypes Ca 2+ -dependently ( K d = 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca 2+ ). NS8593 does not affect the Ca 2+ -activated K channels of intermediate and large conductance (hlk and hBK channels, respectively). NS8593 can also inhibit TRPM7 (melastatin-related TRP cation channel 7) ( IC 50 = 1.6 mM). NS8593 can be used for the study of central nervous system (CNS) related diseases.

Application

Products | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Potassium Channel | Products > Signaling Pathways > TRP Channel

Product Information

• Catalog No.: HY-137952
• CAS No.: 875755-39-8
• Molecular Formula: C17H17N3
• Molecular Weight: 263.34
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source