Toladryl is a derivative of Diphenhydramine ( HY-B0303 ), capable of penetrating the blood-brain barrier and possessing oral activity, as well as antihistamine and anticholinergic activities. The anticholinergic activity of Toladryl is approximately one-tenth that of Diphenhydramine ( HY-B0303 ), and its protective effect against lethal doses of histamine in guinea pigs is 2 to 4 times that of Diphenhydramine ( HY-B0303 ). The side effects of Toladryl are fewer and milder than those of Diphenhydramine ( HY-B0303 ), but at higher doses, it may cause central nervous system symptoms such as insomnia, agitation, and disorientation. Toladryl can be used for research in allergic diseases.
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