PF-06862309 is a PF-06843195 ( HY-131972 ) phosphate ester prodrug. PF-06862309 can be hydrolyzed to PF-06843195 in the presence of alkaline phosphatase . PF-06843195 is a highly selective PI3Kα inhibitor . PF-06862309 can be used for the study of breast cancer with ER + , HER 2- , and PIK3CA mutations.
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