C004019

Overview

C004019 is a BBB-penetrable and small-molecule PROTAC that targets tau . C004019 can simultaneously recruit tau and E3 ligase , and effectively clear tau proteins by promoting the ubiquitination and proteasome-dependent degradation of tau, thereby improving synaptic and cognitive functions in Alzheimer's disease (AD) mice. C004019 can be used in the research of AD and tau protein-related diseases. (Pink: Tau Protein ligand ( HY-138679 ); Blue: VHL ligand ( HY-138678 ); Black: linker ( HY-140189 )).

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Alzheimer's Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Tau Protein

Product Information

• Catalog No.: HY-138669
• CAS No.: 2417159-57-8
• Molecular Formula: C49H70N12O9S2
• Molecular Weight: 1035.29
• Purity: 99.72%
• Storage: -20°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Availability: In-stock

Source

Original product source