BSJ-4-116

Overview

BSJ-4-116 is a PROTAC connected by ligands for Cereblon and CDK . BSJ-4-116 is a highly potent and selective CDK12 degrader ( PROTAC ) with an IC 50 of 6 nM. BSJ-4-116 downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation). BSJ-4-116 exhibits potent antiproliferative effects, alone and in combination with the poly(ADP-ribose) polymerase inhibitor Olaparib ( HY-10162 ). (Pink: CDK12 ligand ( HY-150948 ); Blue: Cereblon ligand ( HY-41547 ); Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > CDK

Product Information

• Catalog No.: HY-139039
• CAS No.: 2519823-34-6
• Molecular Formula: C40H49ClN8O8S
• Molecular Weight: 837.38
• Purity: 99.87%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.08 mg/mL (2.48 mM); Clear solution
• Availability: In-stock

Source

Original product source