GMQ is an acid-sensing ion channel modulator, competitive GABA A R antagonist. GMQ preferentially, potently, competitively inhibits GABAARs . GMQ inhibits α 1 β 2 , α 1 β 2 γ 2 , α 4 β 2 γ 2 and α 5 β 2 γ 2 GABA A R s. GMQ enhances neuronal excitation through inhibition of GABAergic transmission. GMQ has anti-histamine effects in the enteric system, inhibiting gastric acid secretion.
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