MRTX849 ethoxypropanoic acid

Overview

MRTX849 ethoxypropanoic acid incorporates a ligand for KRAS G12C, and a PROTAC linker. MRTX849 ethoxypropanoic acid can be used in the synthesis of PROTAC LC-2 ( HY-137516 ). LC-2 is a potent and first-in-class PROTAC capable of degrading endogenous KRAS G12C ( IC 50 s between 0.25 and 0.76 μM).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Target Protein Ligand-Linker Conjugates | Products > Signaling Pathways > Ras

Product Information

• Catalog No.: HY-139403
• CAS No.: 2561529-98-2
• Molecular Formula: C37H43ClFN7O5
• Molecular Weight: 720.23
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source