ML-SI3

Overview

ML-SI3 is a mixture of cis/trans ML-SI3 ( HY-139426A ), which is a TRPML1/2 channel inhibitor with IC 50 s of 4.7 μM and 1.7 μM, respectively. ML-SI3 also inhibits lysosomal calcium efflux and blocks downstream TRPML1-mediated autophagy . The cis/trans ML-SI3 ( HY-139426A ) components of ML-SI3 are TRPML2 activators with EC 50 s of 3.3 μM and 9.4 μM, respectively.

Application

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Product Information

• Catalog No.: HY-139426
• CAS No.: 891016-02-7
• Molecular Formula: C23H31N3O3S
• Molecular Weight: 429.58
• Purity: 99.91%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (5.82 mM); Clear solution
• Availability: In-stock

Source

Original product source