PF-03622905 is a potent and ATP-competitive PKC inhibitor with IC 50 s of 5.6 nM, 14.5 nM, 13 nM, 37.7 nM, and 74.1 nM for PKCα , PKCβI , PKCβII , PKCγ , and PKCθ , respectively. PF-03622905 shows high specificity for PKC over other protein kinases.
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