PF-04577806

Overview

PF-04577806 is a potent, selective and ATP competitive PKC inhibitor. PF-04577806 shows potent inhibitory activity towards PKCα , PKCβI , PKCβII , PKCγ , and PKCθ with IC 50 s of 2.4 nM, 8.1 nM, 6.9 nM, 45.9 nM, and 29.5 nM, respectively. PF-04577806 can reverse retinal vascular leakage in diabetic rats.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > TGF-beta/Smad | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > SHP2 | Products > Signaling Pathways > PKC

Product Information

• Catalog No.: HY-139467
• CAS No.: 1072100-81-2
• Molecular Formula: C26H37N7O3
• Molecular Weight: 495.62
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source