Gamcemetinib

Overview

Gamcemetinib (CC-99677) is a potent, covalent, and irreversible inhibitor of the mitogen-activated protein (MAP) kinase-activated protein kinase-2 ( MK2 ) pathway in both biochemical ( IC 50 =156.3 nM) and cell based assays ( EC 50 =89 nM). Gamcemetinib is extracted from patent WO2020236636, compound 1.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > MAPKAPK2 (MK2)

Product Information

• Catalog No.: HY-139504
• CAS No.: 1887069-10-4
• Molecular Formula: C22H20ClN5O3S
• Molecular Weight: 469.94
• Purity: 99.06%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 1.5 mg/mL (3.19 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source