BMS-986318

Overview

BMS-986318 is a potent nonbile acid FXR agonist with EC 50 s of 53 and 350 nM in the FXR Gal4 and SRC-1 recruitment assays, respectively. BMS-986318 has a suitable ADME profile, and demonstrates efficacy in the mouse bile duct ligation model of liver cholestasis and fibrosis.BMS-986318 can be used for the research of nonalcoholic steatohepatitis.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > FXR

Product Information

• Catalog No.: HY-139562
• CAS No.: 2314378-09-9
• Molecular Formula: C30H23Cl2F3N4O3
• Molecular Weight: 615.43
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source