AMG 837

Overview

AMG 837 is an orally active, selective GPR40 / FFA1 agonist with an EC 50 of 1.5 nM against human GPR40 . AMG 837 stimulates insulin secretion in a glucose-dependent manner, and effectively improves glycemic control in both normal and diabetic rodent models . AMG 837 binds to the BacA protein and impairs the survival and replication of Brucella . AMG 837 can be used in research related to type 2 diabetes and brucellosis.

Application

Products | Products > Disease Areas > Type 2 Diabetes | Products > Disease Areas > Infection | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Glucose Metabolism | Products > Disease Areas > Bacterial Infection | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Metabolic Disease | Products > Research Areas > Infection | Products > Signaling Pathways > Free Fatty Acid Receptor | Products > Signaling Pathways > Bacterial

Product Information

• Catalog No.: HY-13967
• CAS No.: 865231-46-5
• Molecular Formula: C26H21F3O3
• Molecular Weight: 438.44
• Purity: 98.59%
• Storage: Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (5.70 mM); Clear solution
• Availability: In-stock

Source

Original product source