Tegaserod maleate

Overview

Tegaserod maleate (SDZ-HTF-919) is an orally active serotonin receptor 4 ( HTR4 ; 5-HT 4 R ) agonist and a 5-HT 2B receptor antagonist. Tegaserod maleate has pK i s of 7.5, 8.4 and 7.0 for human recombinant 5-HT 2A , 5-HT 2B and 5-HT 2C receptors, respectively. Tegaserod maleate causes tumor cell apoptosis , blunts PI3K/Akt/mTOR signaling and decreases S6 phosphorylation. Tegaserod maleate has anti-tumor activity and has the potential for irritable bowel syndrome (IBS) research.

Application

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Product Information

• Catalog No.: HY-14153A
• CAS No.: 189188-57-6
• Molecular Formula: C20H27N5O5
• Molecular Weight: 417.46
• Purity: 99.90%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (5.99 mM); Clear solution
• Availability: In-stock

Source

Original product source