PF 477736 (Standard)

Overview

PF 477736 (Standard) is the analytical standard of PF 477736 ( HY-10032 ). This product is intended for research and analytical applications. PF 477736 (PF 00477736) is a potent, selective and ATP-competitive inhibitor of Chk1 , with a Ki of 0.49 nM, it is also a Chk2 inhibitor , with a Ki of 47 nM. PF 477736 shows <100-fold selectivity for Chk1 over VEGFR2, Fms, Yes , Aurora-A, FGFR3, Flt3 , and Ret (IC50=8 (Ki), 10, 14, 23, 23, 25, and 39 nM, respectively). PF 477736 can enhance Gemcitabine antitumor activity in vitro and in vivo.

Application

Products | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Others | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > c-Fms | Products > Signaling Pathways > Aurora Kinase | Products > Signaling Pathways > FGFR | Products > Signaling Pathways > FLT3 | Products > Signaling Pathways > RET | Products > Signaling Pathways > CDK | Products > Signaling Pathways > Checkpoint Kinase (Chk) | Products > Signaling Pathways > Reference Standards | Products > Signaling Pathways > VEGFR | Products > Signaling Pathways > Src

Product Information

• Catalog No.: HY-10032R
• CAS No.: 952021-60-2
• Molecular Formula: C22H25N7O2
• Molecular Weight: 419.48
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source