MS154

Overview

MS154 is a first-in-class E3 ligase cereblon-recruited EGFR degrader with K d values of 1.8 nM and 3.8 nM for EGFR WT and EGFR L858R mutant, respectively. MS154 potently induces degradation of mutant, but not wild-type, EGFR in cancer cell lines in an E3 ligase-dependent manner. MS154 exhibits anticancer effects against lung cancer (blue: E3 ligase ligand ( HY-103596 ); black: linker ( HY-W096167 ); pink: EGFR ligand ( HY-168305 )). (Pink: EGFR ligand ( HY-168305 ); Blue: Cereblon ligand ( HY-103596 ); Black: linker ( HY-W096167 )).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Lung Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > JAK/STAT Signaling | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > EGFR

Product Information

• Catalog No.: HY-141640
• CAS No.: 2550393-21-8
• Molecular Formula: C46H54ClFN8O8
• Molecular Weight: 901.42
• Purity: 99.71%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source