CMPD-39

Overview

CMPD-39 is a selective non-covalent inhibitor of the ubiquitin-specific protease USP30 ( IC 50 =~20 nM), with high selectivity over other DUB family members (1-100 μM). CMPD-39 inhibits the deubiquitinating activity of USP30 , enhances the ubiquitination of mitochondrial proteins TOMM20 and SYNJ2BP ; thus, CMPD-39 promotes phosphoubuitin accumulation, thereby accelerating mitochondrial autophagy ( mitophagy ) and peroxisomal autophagy ( pexophagy ). CMPD-39 significantly restores impaired mitochondrial function in dopaminergic neurons derived from Parkinson's disease patients.

Application

Products | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Parkinson's Disease | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Mitophagy | Products > Signaling Pathways > Deubiquitinase

Product Information

• Catalog No.: HY-141659
• CAS No.: 2242582-40-5
• Molecular Formula: C26H28FN3O4S
• Molecular Weight: 497.58
• Purity: 99.74%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (5.02 mM); Clear solution
• Availability: In-stock

Source

Original product source