MS4322

Overview

MS4322 (YS43-22) is a specific PRMT5 PROTAC degrader. MS4322 reduces the PRMT5 protein level with a DC 50 of 1.1 μM in MCF-7 cells. MS4322 inhibits the methyltransferase activity of PRMT5 with an IC 50 of 18 nM. MS4322 promotes ubiquitination and degradation of PRMT5 . MS4322 can be used for the research of breast cancer , lung cancer , and hepatocellular cancer . (Pink: PRMT5 ligand ( HY-173092 ); Blue: E3 ligase ligand HY-112078); Black: linker ( HY-124780 ); E3+linker (HY-173093 )). (Pink: Histone Methyltransferase ligand ( HY-173092 ); Blue: VHL ligand ( HY-112078 ); Black: linker ( HY-124780 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Histone Methyltransferase

Product Information

• Catalog No.: HY-141877
• CAS No.: 2375432-47-4
• Molecular Formula: C55H76N10O12S
• Molecular Weight: 1101.32
• Purity: 99.14%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (2.27 mM); Clear solution
• Availability: In-stock

Source

Original product source