Z-Leu-Arg-AMC

Overview

Z-Leu-Arg-AMC is a fluorogenic peptide substrate for cysteine proteases (e.g., Cathepsin ) (Ex=350 nm，Em=460 nm). Z-Leu-Arg-AMC is preferentially cleaved by Cathepsin K and S under weakly acidic conditions, while its hydrolysis relies on residual Cathepsin S activity at neutral pH. Z-Leu-Arg-AMC serves as a substrate for recombinant Sphenophorus levis Cathepsin L , falcipain-2 , falcipain-3 , berghepain-2 , knowlepain-2 , vivapain-2 , as well as falcipain-2 chimeras and constructs. It enables quantitative detection of cysteine protease activity in human inflammatory bronchoalveolar lavage fluid via fluorescence generation. Z-Leu-Arg-AMC can be used in research related to pulmonary inflammatory diseases and malaria.

Application

Products | Products > Disease Areas > Pathogens Infection | Products > Disease Areas > Respiratory Inflammation | Products > Disease Areas > Parasitic Infection | Products > Disease Areas > Pneumonia | Products > Disease Areas > Infection | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Lower Respiratory Inflammation | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Infection | Products > Signaling Pathways > Cathepsin | Products > Signaling Pathways > Parasite

Product Information

• Catalog No.: HY-142021
• CAS No.: 156192-32-4
• Molecular Formula: C30H38N6O6
• Molecular Weight: 578.66
• Purity: 99.24%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Availability: In-stock

Source

Original product source