LY 78335

Overview

LY 78335 (DCMB) is a brain-penetrant phenylethanolamine-N-methyltransferase (PNMT) inhibitor with a K i of 0.09 μM. LY 78335 acts as an α₂-adrenoceptor inhibitor with an IC 50 of 10 μM. LY 78335 increases spontaneous locomotor activity in rats. LY 78335 increases extracellular concentration of 3-methoxy-4-hydroxyphenylglycol (MHPG) in rat hypothalamus. LY 78335 prevents growth hormone (GH) secretion in rats. LY 78335 can be used for the research of depression.

Application

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Product Information

• Catalog No.: HY-142110
• CAS No.: 39226-94-3
• Molecular Formula: C8H9Cl2N
• Molecular Weight: 190.07
• Purity: 99.19%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (13.15 mM); Clear solution
• Availability: In-stock

Source

Original product source