GNF2133

Overview

GNF2133 is a potent, selective and orally active DYRK1A inhibitor with IC 50 s of 0.0062, >50 µM for DYRK1A and GSK3β, respectively. GNF2133 shows good proliferation potency and efficacy on rat and human primary β-cell. GNF2133 significantly improves glucose disposal capacity and increases insulin secretion. GNF2133 has the potential for the research of type 1 diabetes.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Lipid Metabolism | Products > Disease Areas > Glucose Metabolism | Products > Disease Areas > Obesity | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > DYRK

Product Information

• Catalog No.: HY-142295
• CAS No.: 2561414-56-8
• Molecular Formula: C24H30N6O2
• Molecular Weight: 434.53
• Purity: 99.67%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 0.5 mg/mL (1.15 mM); Clear solution
• Availability: In-stock

Source

Original product source