BCPyr

Overview

BCPyr is a PROTAC degrader targeting cIAP1 and BTK , with a K d of 262 nM for human cIAP1 , and K d values of 262 nM and 692 nM for human BTK . BCPyr binds to the Bir3 domain of cIAP1 , recruits BTK to cIAP1 , and mediates the ubiquitination and degradation of BTK . BCPyr acts as a degrader, ternary complex stabilizer, cooperative binder, and higher-order assembly inducer. BCPyr can be used in studies related to leukemia and lymphoma. (Pink: Btk ligand ( HY-168314 ); Blue: cIAP1 ligand ( HY-135997 ); Black: linker ( HY-168315 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > SNIPERs | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Btk | Products > Signaling Pathways > IAP

Product Information

• Catalog No.: HY-142621
• CAS No.: 2669844-82-8
• Molecular Formula: C58H65F2N11O8
• Molecular Weight: 1082.20
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source