PROTAC IRAK3 degrader-1 is a potent and selective IRAK3 degrader with a DC 50 of 0.002 μM. PROTAC IRAK3 degrader-1 induces proteasome-dependent degradation of IRAK3 via ternary complex formation with IRAK3 and CRBN . PROTAC IRAK3 degrader-1 can be used for cancer research. (Pink: IRAK3 Target protein ligand; Blue: Cereblon ligand ( HY-14658 ); Black: linker).
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