Entacapone-d 10

Overview

Entacapone-d 10 is the deuterium labeled Entacapone. Entacapone is a potent, reversible, peripherally acting and orally active catechol-O-methyltransferase ( COMT ) inhibitor. Entacapone inhibits COMT from rat brain, erythrocytes and liver with IC 50 values of 10 nM, 20 nM, and 160 nM, respectively. Entacapone is selective for COMT over other catecholamine metabolizing enzymes , including MAO-A , MAO-B , phenolsulphotransferase M (PST-M) and PST-P ( IC 50 s>50 μM). Entacapone can be used for the research of Parkinson's disease. Entacapone serves as a inhibitor of FTO demethylation with an IC 50 of 3.5 μM, can be used for the research of metabolic disorders.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > COMT

Product Information

• Catalog No.: HY-14280S
• CAS No.: 1185241-19-3
• Molecular Formula: C14H5D10N3O5
• Molecular Weight: 315.35
• Purity: 98.6%
• Storage: -20°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Availability: In-stock

Source

Original product source