DHFR-IN-1 (compound 12) is a potent and selective DHFR ( dihydrofolate reductase )inhibitor, with an IC 50 of 40.71 nM. DHFR-IN-1 exhibits promising antibacterial activity against gram-positive and gram-negative bacteria. DHFR-IN-1 exhibits moderate antifungal activities. DHFR-IN-1 exhibits a high synergistic effect with Levofloxacin ( HY-B0330 ), where the FIC (fractional inhibitory concentration index) value is 0.249.
Products | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Signaling Pathways > Bacterial | Products > Signaling Pathways > Fungal
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