HL-8

Overview

HL-8 is a PI3Kα PROTAC degrader. HL-8 promotes the ubiquitination and degradation of PI3Kα . HL-8 reduces pAKT levels. HL-8 has anticancer activity against colon and cervical cancer (Pink: PI3Kα ligand ( HY-143277 ); Blue: E3 ligase VHL ligand ( HY-138678 ); Black: linker ( HY-W002042 )). (Pink: PI3Kα ligand ( HY-143277 ); Blue: VHL ligand ( HY-138678 ); Black: linker ( HY-W002042 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > PI3K | Products > Signaling Pathways > Akt

Product Information

• Catalog No.: HY-143275
• CAS No.: 2766352-64-9
• Molecular Formula: C57H59F2N11O9S2
• Molecular Weight: 1144.27
• Purity: 99.17%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (2.18 mM); Clear solution
• Availability: In-stock

Source

Original product source