PF15

Overview

PF15 is an orally active FLT3-ITD PROTAC degrader with a DC 50 of 76.7 nM and an IC 50 of 36 nM against FLT3-ITD. PF15 induces FLT3-ITD protein degradation, thereby downregulating its phosphorylation level. PF15 inhibits the proliferation of FLT3-ITD-positive cells and reduces the phosphorylation level of STAT5 , a downstream molecule of FLT3-ITD. PF15 exhibits efficacy in in vivo xenograft models of acute myeloid leukemia and prolongs survival. PF15 can be used for the research of acute myeloid leukemia. (Pink: FLT3 Target protein ligand; Blue: Cereblon ligand ( HY-A0003 ); Black: linker).

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > JAK/STAT Signaling | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > FLT3 | Products > Signaling Pathways > STAT

Product Information

• Catalog No.: HY-143286
• CAS No.: 2892631-70-6
• Molecular Formula: C44H49N13O6
• Molecular Weight: 855.94
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Solubility: ≥ 2.5 mg/mL (2.92 mM); Clear solution

Source

Original product source