NTPDase-IN-1 (compound 5a) is a selective NTPDase inhibitor with IC 50 s of 0.05, 0.23 and 0.54 µM for h-NTPDase-1/-2/-8 , respectively. NTPDase-IN-1 non-competitively inhibits h-NTPDase-1/-2 with a K m of 21 µM for h-NTPDase-1 . NTPDase-IN-1 can be used in studies of cancer , immunologic disorders as well as bacterial infections.
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