Nigericin sodium salt

Overview

Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that act as a K + /H + ionophore , promoting K + /H + exchange across mitochondrial membranes. Nigericin sodium salt is a NLRP3 activator. Nigericin sodium salt shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt / β-catenin signals. Nigericin sodium salt induces pyroptosis through caspase 1 /GSDMD in TNBC.

Application

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Product Information

• Catalog No.: HY-100381
• CAS No.: 28643-80-3
• Molecular Formula: C40H67NaO11
• Molecular Weight: 746.94
• Purity: 99.60%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (3.35 mM); Clear solution
• Availability: In-stock

Source

Original product source