Ticlopidine

Overview

Ticlopidine (PCR 5332), an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC 50 of 81.7 μM. Ticlopidine blocks several NTPDase isoenzymes with IC 50 s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively. Ticlopidine is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine inhibits CYP2C9 and CYP3A4 with IC 50 s of 26.0 and 32.3 μM, respectively.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Cardiovascular Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > NTPDase | Products > Signaling Pathways > Cytochrome P450

Product Information

• Catalog No.: HY-100386
• CAS No.: 55142-85-3
• Molecular Formula: C14H14ClNS
• Molecular Weight: 263.79
• Purity: 99.74%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (9.48 mM); Clear solution
• Availability: In-stock

Source

Original product source