GSK-163090 dihydrochloride is a potent, selective and orally active 5-HT 1A/1B/1D receptor antagonist with pK i values of 9.4, 8.5 and 9.7, respectively. GSK-163090 dihydrochloride inhibits the functional activity of serotonin reuptake transporter (SerT) with a pK i value of 6.1. GSK-163090 dihydrochloride has antidepressant and anxiolytic activities.
Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > 5-HT Receptor | Products > Signaling Pathways > Dopamine Receptor
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