PROTAC TTK degrader-2

Overview

PROTAC TTK degrader-2 is a threonine tyrosine kinase (TTK) PROTAC degrader with a DC 50 of 3.1 nM in COLO-205 cells. PROTAC TTK degrader-2 induces proteasome-mediated degradation of TTK. It inhibits the proliferation of colorectal cancer cells. In colorectal cancer xenograft mouse models, PROTAC TTK degrader-2 mediates target degradation and exerts anticancer activity. PROTAC TTK degrader-2 can be used in colorectal cancer-related research. (Pink: Mps1 Target protein ligand; Blue: Cereblon ligand ( HY-W243404 ); Black: linker ( HY-69220 )).

Application

Products | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Colorectal Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cytoskeleton | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Mps1

Product Information

• Catalog No.: HY-143905
• CAS No.: 2953426-48-5
• Molecular Formula: C49H57N9O7
• Molecular Weight: 884.03
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source