AChE/BuChE-IN-1

Overview

AChE/BuChE-IN-1 (Compound 1), a chrysin derivative, is a selective butyrylcholinesterase (BuChE) inhibitor with an IC 50 of 0.48 μM. AChE/BuChE-IN-1 inhibits acetylcholinesterase ( AChE ) with an IC 50 of 7.16 μM. AChE/BuChE-IN-1 shows strong scavenging ·OH activities with a IC 50 of 0.1674 μM. AChE/BuChE-IN-1 inhibits reactive oxygen species (ROS), Aβ 1-42 aggregation (self-, Cu 2+ -induced, AChE-induced). AChE/BuChE-IN-1 has high BBB permeability and bioavailability and low cell toxicity. AChE/BuChE-IN-1 has the potential for Alzheimer' disease (AD) research.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Free Radical Scavengers | Products > Signaling Pathways > Cholinesterase (ChE)

Product Information

• Catalog No.: HY-144392
• CAS No.: 84212-49-7
• Molecular Formula: C19H19NO4
• Molecular Weight: 325.36
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source