MtTMPK-IN-2 (compound 15) is a potent Mycobacterium tuberculosis thymidylate kinase ( Mt TMPK) inhibitor with an IC 50 value of 1.1 μM. MtTMPK-IN-2 has inhibitory activity against Mtb H37Rv (MIC = 12.5 μM). MtTMPK-IN-2 exhibits certain cytotoxicity in human fibroblast cells MRC-5 (EC 50 = 6.1 μM). MtTMPK-IN-2 can be used for researching tuberculosis.
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