LOC14

Overview

LOC14 is a potent Protein disulfide isomerase ( PDI ) inhibitor with EC 50 and K d values of 500 nM and 62 nM, respectively. LOC14 exhibits high stability in mouse liver microsomes and blood plasma, low intrinsic microsome clearance, and low plasma-protein binding. LOC14 inhibits PDIA3 activity, decreases intramolecular disulfide bonds and subsequent oligomerization (maturation) of HA in lung epithelial cells.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > PDI

Product Information

• Catalog No.: HY-100432
• CAS No.: 877963-94-5
• Molecular Formula: C16H19N3O2S
• Molecular Weight: 317.41
• Purity: 98.0%
• Storage: 4°C, protect from light * The compound is unstable in solutions, freshly prepared is recommended.
• Solubility: ≥ 2.08 mg/mL (6.55 mM); Clear solution
• Availability: In-stock

Source

Original product source