HIV-1 protease-IN-1 (Compound 1e) is a potent inhibitor of HIV-1 protease with an IC 50 of 90 pM. HIV-1 protease-IN-1 demonstrates antiviral activity with EC 50 value of 89 nM against B-HIV. HIV-1 protease-IN-1 exhibits activity with EC 50 value of 13.59 nM against C-HIV strain ZM246. HIV-1 protease-IN-1 shows remarkable activity with EC 50 value of 8.23 nM against C-HIV strain Indie [1] .
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