Tesofensine (NS-2330) is a triple monoamine reuptake inhibitor inducing a potent inhibition of the re-uptake process in the synaptic cleft of the neurotransmitters dopamine ( DA ; IC 50 =6.5 nM), norepinephrine ( NE ; IC 50 =1.7 nM), and serotonin ( 5-HT ; IC 50 =11 nM), and with potentials as an anti-obesity agent. Tesofensine is a CNS acting anti-obesity agent.
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