HQ461

Overview

HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation. HQ461-mediated degradation of cyclin K impairs CDK12 function, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.

Application

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Product Information

• Catalog No.: HY-144981
• CAS No.: 1226443-41-9
• Molecular Formula: C15H15N5OS2
• Molecular Weight: 345.44
• Purity: 98.10%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source