NP3-146

Overview

NP3-146 is a NLRP3 inflammasome inhibitor through locking the NACHT domain of NLRP3 . NP3-146 shows potent inhibitory activity against IL-1β release with an IC 50 value of 0.171 μM in LPS ( HY-D1056 )/Nigericin ( HY-127019 )-stimulated BMDM cells. NP3-146 regulates the levels of cleaved Caspase-1 and cleaved IL-1β in cell supernatants. NP3-146 can be used for the research of inflammatory diseases.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > NOD-like Receptor (NLR) | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > Caspase

Product Information

• Catalog No.: HY-145087
• CAS No.: 210826-47-4
• Molecular Formula: C20H27ClN2O5S
• Molecular Weight: 442.96
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source