NP3-146 sodium

Overview

NP3-146 sodium is a NLRP3 inflammasome inhibitor through locking the NACHT domain of NLRP3 . NP3-146 sodium shows potent inhibitory activity against IL-1β release with an IC 50 value of 0.171 μM in LPS ( HY-D1056 )/Nigericin ( HY-127019 )-stimulated BMDM cells. NP3-146 sodium regulates the levels of cleaved Caspase-1 and cleaved IL-1β in cell supernatants. NP3-146 sodium can be used for the research of inflammatory diseases.

Application

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Product Information

• Catalog No.: HY-145087A
• CAS No.: 1995068-96-6
• Molecular Formula: C20H27ClN2NaO5S
• Molecular Weight: 465.95
• Purity: 99.26%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (5.37 mM); Clear solution
• Availability: In-stock

Source

Original product source