AL-8810 is a potent and selective antagonist of the PGF 2α receptor ( FP receptor). AL-8810 is an activator of MAPK and ERK1/2 . The K i of the FP receptor of mouse 3T3 cells and rat A7r5 cells are 0.2±0.06 μM and 0.4±0.1 μM, respectively. AL-8810 can be used in the study of elevated intraocular pressure (OHT) and primary open-angle glaucoma (POAG).
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