SHP2-D26

Overview

SHP2-D26 is a SHP2 PROTAC degrader with DC 50 values of 6.0 nM (KYSE520 cells) and 2.6 nM (MV4;11 cells), respectively. SHP2-D26 inhibits ERK phosphorylation, upregulates Bim levels, downregulates Mcl-1 levels, and induces cell cycle arrest and apoptosis . SHP2-D26 can be used in studies related to esophageal cancer , acute myeloid leukemia and non-small cell lung cancer . (Pink: SHP2 ligand ( HY-176797 ); Blue: VHL ligand ( HY-150803 ); Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Respiratory Cancer | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Blood Disease | Products > Disease Areas > Non-Small Cell Lung Cancer | Products > Disease Areas > Acute Myeloid Leukemia | Products > Disease Areas > Esophageal Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > ERK | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > SHP2 | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-145162
• CAS No.: 2458219-65-1
• Molecular Formula: C56H79ClN12O6S2
• Molecular Weight: 1115.89
• Purity: 95.83%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source