XY-06-007

Overview

XY-06-007 is a selective and potent bump-and-hole (B&H)- PROTAC BRD4 BD1 L94V degrader. XY-06-007 shows a DC 50, 6 h of 10 nM against BRD4 BD1 L94V with no degradation of off-targets. XY-06-007 demonstrates suitable pharmacokinetics for in vivo studies. (Pink: BRD4 BD1L94V ligand ( HY-184949 ); Blue: Cereblon ligand ( HY-103597 ); Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Epigenetic Reader Domain

Product Information

• Catalog No.: HY-145226
• CAS No.: 2757045-94-4
• Molecular Formula: C41H41ClN8O8
• Molecular Weight: 809.27
• Purity: 98.9%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source