MS98

Overview

MS98 is a potent and selective PROTAC AKT degrader. MS98 depletes cellular total AKT (T-AKT) with the DC 50 value of 78 nM. MS98 binds to AKT1 , AKT2 , and AKT3 with K d s of 4 nM, 140 nM, and 8.1 nM, respectively. (Pink: Akt ligand ( HY-15186 ); Blue: VHL ligand ( HY-112078 ); Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Akt

Product Information

• Catalog No.: HY-145281
• CAS No.: 2376137-31-2
• Molecular Formula: C58H81ClN10O7S
• Molecular Weight: 1097.84
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source