Clozapine

Overview

Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a K i of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with K i s of 9.5 nM and 4 nM, respectively. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor ( EC 50 =11 nM).

Application

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Product Information

• Catalog No.: HY-14539
• CAS No.: 5786-21-0
• Molecular Formula: C18H19ClN4
• Molecular Weight: 326.83
• Purity: 99.84%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 1 year , -20°C, 6 months
• Solubility: ≥ 2.5 mg/mL (7.65 mM); Clear solution
• Availability: In-stock

Source

Original product source