PAIR2

Overview

PAIR2 is a highly selective inhibitor targeting the kinase domain of human IRE1α , with a K i value of 8.8 nM against human IRE1α . PAIR2 fully occupies the ATP-binding site of the IRE1α kinase domain, partially antagonizes the ribonuclease activity of IRE1α, specifically inhibits regulated IRE1α-dependent decay ( RIDD ) and its mediated substrate cleavage, while preserving the splicing function of Xbp1 mRNA . PAIR2 also promotes the differentiation of B cells into plasma cells, blocks IRE1α-induced cell apoptosis , and restores the expression of Fgfr2 mRNA in AT2 cells. PAIR2 effectively reaches a steady-state concentration in the lung tissues of Mus musculus, and serves as an important tool for investigating the function of the IRE1α signaling pathway in diseases such as pulmonary fibrosis.

Application

Products | Products > Disease Areas > Lung Fibrosis | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Pulmonary Disease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > IRE1 | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > FGFR

Product Information

• Catalog No.: HY-145425
• CAS No.: 2771006-54-1
• Molecular Formula: C27H26F4N6O3S
• Molecular Weight: 590.59
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source