KT-474

Overview

KT-474 (KYM-001; PROTAC IRAK4 degrader-7) is an orally active PROTAC IRAK4 degrader with anti-tumor effects. KT-474 inhibits the cell cycle and induces apoptosis . KT-474 induces tumor regression in a xenograft model of MYD88-mutated ABC DLBCL. (Pink: IRAK4 ligand ( HY-145484 ); Blue: Cereblon ligand ( HY-45512 ); Black: linker).

Application

Products | Products > Disease Areas > Allergy | Products > Disease Areas > Skin Inflammation | Products > Disease Areas > Atopic Dermatitis | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > IRAK | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-145483
• CAS No.: 2432994-31-3
• Molecular Formula: C44H49F2N11O6
• Molecular Weight: 865.93
• Purity: 99.77%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (2.89 mM); Clear solution
• Availability: In-stock

Source

Original product source