KT-474 hydrochloride

Overview

KT-474 (KYM-001; PROTAC IRAK4 degrader-7) hydrochloride is an orally active PROTAC IRAK4 degrader with anti-tumor effects. KT-474 inhibits the cell cycle and induces apoptosis . KT-474 induces tumor regression in a xenograft model of MYD88-mutated ABC DLBCL. (Pink: IRAK4 ligand ( HY-145484 ); Blue: Cereblon ligand ( HY-45512 ); Black: linker).

Application

Products | Products > Disease Areas > Skin Inflammation | Products > Disease Areas > Atopic Dermatitis | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Allergy | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > IRAK | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-145483A
• CAS No.: 2751703-31-6
• Molecular Formula: C44H50ClF2N11O6
• Molecular Weight: 902.39
• Purity: ≥98.0%
• Storage: Store at room temperature, keep dry and cool. In solvent -80°C, 1 year , -20°C, 6 months
• Availability: In-stock

Source

Original product source